Pantothenate synthetase
From Proteopedia
(Difference between revisions)
| Line 6: | Line 6: | ||
Pantothenate (vitamin B5) biosynthesis is essential for the virulence of ''Mycobacterium tuberculosis'' thus its blockage can be used as a potential drug target. | Pantothenate (vitamin B5) biosynthesis is essential for the virulence of ''Mycobacterium tuberculosis'' thus its blockage can be used as a potential drug target. | ||
== Structural highlights == | == Structural highlights == | ||
| - | + | PS active site is located at the C-terminal of the central parallel β sheet. In this structure the pantoate substrate electron density is well defined in one subunit while the nucleotide electron density is well defined in the other<ref>PMID:12717031</ref>. | |
</StructureSection> | </StructureSection> | ||
==3D structures of pantothenate synthetase== | ==3D structures of pantothenate synthetase== | ||
Revision as of 06:24, 15 June 2016
| |||||||||||
3D structures of pantothenate synthetase
Updated on 15-June-2016
References
- ↑ Wang S, Eisenberg D. Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate. Protein Sci. 2003 May;12(5):1097-108. PMID:12717031
