Pantothenate synthetase
From Proteopedia
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<StructureSection load='1n2e' size='350' side='right' caption='Pantothenate synthetase complex with pantoate, AMPPNP (stick model), sulfate, Mg+2 ion (green), ethanol and glycerol (PDB entry [[1n2e]])' scene=''> | <StructureSection load='1n2e' size='350' side='right' caption='Pantothenate synthetase complex with pantoate, AMPPNP (stick model), sulfate, Mg+2 ion (green), ethanol and glycerol (PDB entry [[1n2e]])' scene=''> | ||
== Function == | == Function == | ||
| - | '''Pantothenate synthetase''' (PS) catalyzes the ATP-dependent condensation of pantoate and β-alanine to form pantothenate. | + | '''Pantothenate synthetase''' (PS) catalyzes the ATP-dependent condensation of pantoate and β-alanine to form pantothenate<ref>PMID:17932772</ref>. |
== Relevance == | == Relevance == | ||
| - | Pantothenate (vitamin B5) biosynthesis is essential for the virulence of ''Mycobacterium tuberculosis'' thus its blockage can be used as a potential drug target. | + | Pantothenate (vitamin B5) biosynthesis is essential for the virulence of ''Mycobacterium tuberculosis'' thus its blockage can be used as a potential drug target<ref>PMID:16460002</ref>. |
== Structural highlights == | == Structural highlights == | ||
PS active site is located at the C-terminal of the central parallel β sheet. In this structure the pantoate substrate electron density is well defined in one subunit while the nucleotide electron density is well defined in the other<ref>PMID:12717031</ref>. | PS active site is located at the C-terminal of the central parallel β sheet. In this structure the pantoate substrate electron density is well defined in one subunit while the nucleotide electron density is well defined in the other<ref>PMID:12717031</ref>. | ||
Revision as of 06:28, 15 June 2016
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3D structures of pantothenate synthetase
Updated on 15-June-2016
References
- ↑ Jonczyk R, Ronconi S, Rychlik M, Genschel U. Pantothenate synthetase is essential but not limiting for pantothenate biosynthesis in Arabidopsis. Plant Mol Biol. 2008 Jan;66(1-2):1-14. Epub 2007 Oct 12. PMID:17932772 doi:http://dx.doi.org/10.1007/s11103-007-9248-6
- ↑ Wang S, Eisenberg D. Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action. Biochemistry. 2006 Feb 14;45(6):1554-61. PMID:16460002 doi:10.1021/bi051873e
- ↑ Wang S, Eisenberg D. Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate. Protein Sci. 2003 May;12(5):1097-108. PMID:12717031
