PDZ and LIM domain protein
From Proteopedia
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<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''> | <StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''> | ||
| - | + | == Function == | |
'''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]]. | '''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure.<br /> For details on PDLIM1 see [[Group:MUZIC:ALP]].<br />For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]]. | ||
*'''PDLIM1''' promotes cell attachment at the cytoskeleton.<br /> | *'''PDLIM1''' promotes cell attachment at the cytoskeleton.<br /> | ||
*'''PDLIM2''' may have a role in bringing proteins to the cytoskeleton.<br /> | *'''PDLIM2''' may have a role in bringing proteins to the cytoskeleton.<br /> | ||
| + | *'''PDLIM3''' may have a role in organizing actin filament arrays within muscle cells.<br /> | ||
| + | *'''PDLIM4''' is a Zn+2 ion binding protein.<br /> | ||
*'''PDLIM5''' has important role in heart development by scaffolding PKC to the Z-disk region.<br /> | *'''PDLIM5''' has important role in heart development by scaffolding PKC to the Z-disk region.<br /> | ||
*'''PDLIM7''' is an adaptor protein localizing the LIM-binding proteins to muscle tissues.<br /> | *'''PDLIM7''' is an adaptor protein localizing the LIM-binding proteins to muscle tissues.<br /> | ||
Revision as of 10:17, 15 June 2016
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3D structures of PDZ and LIM domain protein
Updated on 15-June-2016
