Peptidyl-prolyl cis-trans isomerase
From Proteopedia
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== Function == | == Function == | ||
| - | '''Peptidyl-prolyl cis-trans isomerase''' (PPIase) interconverts cis and trans isomers of proline. PPIase functions as a protein folding chaperone. | + | '''Peptidyl-prolyl cis-trans isomerase''' (PPIase) interconverts cis and trans isomers of proline. PPIase functions as a protein folding chaperone.<br /> |
| + | * '''PPIase Pin1''' isomerizes phospho-serine/threonine proline motifs. The deregulation of Pin1 may be involved in cancer and Alzheimer Disease. Pin1 consists of 2 domains: the WW domain recognizes the pSer/pThr Pro motif and the PPIase domain contains the catalytic site.<br /> | ||
| + | * '''PPIase Mip''' (macrophage infectivity potentiator) is required for optimal infection of macrophages by some parasites.<br /> | ||
| + | * '''PPIase SlyD''' acts as a chaperone and speeds up protein folding. | ||
For various types of PPIase see:<br /> | For various types of PPIase see:<br /> | ||
Revision as of 09:05, 20 June 2016
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3D Structures of peptidyl-prolyl cis-trans isomerase
Updated on 20-June-2016
References
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
