Peptidyl-prolyl cis-trans isomerase
From Proteopedia
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<StructureSection load='1f8a' size='340' side='right' caption='Human PPIase complex with phosphoserine containing peptide (green) (PDB code [[1f8a]]).' scene=''> | <StructureSection load='1f8a' size='340' side='right' caption='Human PPIase complex with phosphoserine containing peptide (green) (PDB code [[1f8a]]).' scene=''> | ||
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== Function == | == Function == | ||
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'''Peptidyl-prolyl cis-trans isomerase''' (PPIase) interconverts cis and trans isomers of proline. PPIase functions as a protein folding chaperone.<br /> | '''Peptidyl-prolyl cis-trans isomerase''' (PPIase) interconverts cis and trans isomers of proline. PPIase functions as a protein folding chaperone.<br /> | ||
* '''PPIase Pin1''' isomerizes phospho-serine/threonine proline motifs<ref>PMID:24173213</ref>. The deregulation of Pin1 may be involved in cancer and Alzheimer Disease. Pin1 consists of 2 domains: the WW domain recognizes the pSer/pThr Pro motif and the PPIase domain contains the catalytic site.<br /> | * '''PPIase Pin1''' isomerizes phospho-serine/threonine proline motifs<ref>PMID:24173213</ref>. The deregulation of Pin1 may be involved in cancer and Alzheimer Disease. Pin1 consists of 2 domains: the WW domain recognizes the pSer/pThr Pro motif and the PPIase domain contains the catalytic site.<br /> | ||
Revision as of 10:01, 20 June 2016
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3D Structures of peptidyl-prolyl cis-trans isomerase
Updated on 20-June-2016
References
- ↑ Guito J, Gavina A, Palmeri D, Lukac DM. The cellular peptidyl-prolyl cis/trans isomerase Pin1 regulates reactivation of Kaposi's sarcoma-associated herpesvirus from latency. J Virol. 2014 Jan;88(1):547-58. doi: 10.1128/JVI.02877-13. Epub 2013 Oct 30. PMID:24173213 doi:http://dx.doi.org/10.1128/JVI.02877-13
- ↑ Fischer G, Bang H, Ludwig B, Mann K, Hacker J. Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activity. Mol Microbiol. 1992 May;6(10):1375-83. PMID:1379319
- ↑ Quistgaard EM, Nordlund P, Low C. High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA. FASEB J. 2012 Jun 26. PMID:22735173 doi:10.1096/fj.12-208397
- ↑ McClements L, Annett S, Yakkundi A, Robson T. The Role of Peptidyl Prolyl Isomerases in Aging and Vascular Diseases. Curr Mol Pharmacol. 2015;9(2):165-79. PMID:25986561
- ↑ Westerman ST. Tasting instilled otologic drops is not a reliable test of eustachian tube function. Arch Otolaryngol Head Neck Surg. 2000 Aug;126(8):1042. PMID:10922246
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