1j77
From Proteopedia
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|PDB= 1j77 |SIZE=350|CAPTION= <scene name='initialview01'>1j77</scene>, resolution 1.50Å | |PDB= 1j77 |SIZE=350|CAPTION= <scene name='initialview01'>1j77</scene>, resolution 1.50Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN IX CONTAINING FE'>HEM</scene> | + | |LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Heme_oxygenase Heme oxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.3 1.14.99.3] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Heme_oxygenase Heme oxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.3 1.14.99.3] </span> |
|GENE= hemO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 Neisseria meningitidis]) | |GENE= hemO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 Neisseria meningitidis]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1qq8|1QQ8]], [[1dve|1DVE]], [[1dvg|1DVG]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j77 OCA], [http://www.ebi.ac.uk/pdbsum/1j77 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j77 RCSB]</span> | ||
}} | }} | ||
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[[Category: Wilks, A.]] | [[Category: Wilks, A.]] | ||
[[Category: Zhu, W.]] | [[Category: Zhu, W.]] | ||
| - | [[Category: HEM]] | ||
[[Category: distal helix]] | [[Category: distal helix]] | ||
[[Category: proximal histidine]] | [[Category: proximal histidine]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:29:34 2008'' |
Revision as of 18:29, 30 March 2008
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| , resolution 1.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | hemO (Neisseria meningitidis) | ||||||
| Activity: | Heme oxygenase, with EC number 1.14.99.3 | ||||||
| Related: | 1QQ8, 1DVE, 1DVG
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Gram-negative Bacterial Heme Oxygenase Complexed with Heme
Overview
We report the crystal structure of heme oxygenase from the pathogenic bacterium Neisseria meningitidis at 1.5 A and compare and contrast it with known structures of heme oxygenase-1 from mammalian sources. Both the bacterial and mammalian enzymes share the same overall fold, with a histidine contributing a ligand to the proximal side of the heme iron and a kinked alpha-helix defining the distal pocket. The distal helix differs noticeably in both sequence and conformation, and the distal pocket of the Neisseria enzyme is substantially smaller than in the mammalian enzyme. Key glycine residues provide the flexibility for the helical kink, allow close contact of the helix backbone with the heme, and may interact directly with heme ligands.
About this Structure
1J77 is a Single protein structure of sequence from Neisseria meningitidis. Full crystallographic information is available from OCA.
Reference
Crystal structure of heme oxygenase from the gram-negative pathogen Neisseria meningitidis and a comparison with mammalian heme oxygenase-1., Schuller DJ, Zhu W, Stojiljkovic I, Wilks A, Poulos TL, Biochemistry. 2001 Sep 25;40(38):11552-8. PMID:11560504
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