4zr5
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Soluble rabbit neprilysin in complex with phosphoramidon== | |
| - | + | <StructureSection load='4zr5' size='340' side='right' caption='[[4zr5]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zr5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZR5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZR5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RDF:N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN'>RDF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xbh|4xbh]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Neprilysin Neprilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.11 3.4.24.11] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zr5 OCA], [http://pdbe.org/4zr5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zr5 RCSB], [http://www.ebi.ac.uk/pdbsum/4zr5 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NEP_RABIT NEP_RABIT]] Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.[UniProtKB:P08473] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Neprilysin]] | ||
[[Category: Grochulski, P]] | [[Category: Grochulski, P]] | ||
| - | [[Category: Labiuk, S | + | [[Category: Labiuk, S L]] |
[[Category: Sygusch, J]] | [[Category: Sygusch, J]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Neutral endopeptidase]] | ||
| + | [[Category: Phosphoramidon]] | ||
| + | [[Category: Zn-dependent]] | ||
Revision as of 15:17, 20 June 2016
Soluble rabbit neprilysin in complex with phosphoramidon
| |||||||||||
