5er5
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Calcium-loaded S100B bound to SC1990== | |
| - | + | <StructureSection load='5er5' size='340' side='right' caption='[[5er5]], [[Resolution|resolution]] 1.26Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5er5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ER5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ER5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ET:ETHIDIUM'>ET</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5er4|5er4]], [[5dkr|5dkr]], [[4pez|4pez]]</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5er5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5er5 OCA], [http://pdbe.org/5er5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5er5 RCSB], [http://www.ebi.ac.uk/pdbsum/5er5 PDBsum]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Alasady, M J]] | ||
| + | [[Category: Aligholizadeh, E]] | ||
| + | [[Category: Cavalier, M C]] | ||
[[Category: Fang, L]] | [[Category: Fang, L]] | ||
| - | [[Category: | + | [[Category: MacKerell, A D]] |
| - | [[Category: | + | [[Category: Melville, Z E]] |
| - | [[Category: | + | [[Category: Pierce, A D]] |
| - | [[Category: | + | [[Category: Weber, D J]] |
| - | [[Category: | + | [[Category: Wilder, P T]] |
| - | [[Category: | + | [[Category: Calcium binding]] |
| - | [[Category: | + | [[Category: Complex]] |
| + | [[Category: Covalent inhibitor]] | ||
| + | [[Category: Malignant melanoma]] | ||
| + | [[Category: Metal binding protein-inhibitor complex]] | ||
Revision as of 15:22, 20 June 2016
Crystal Structure of Calcium-loaded S100B bound to SC1990
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