This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5fyn
From Proteopedia
(Difference between revisions)
m (Protected "5fyn" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Sub-tomogram averaging of Tula virus glycoprotein spike== | |
| + | <StructureSection load='5fyn' size='340' side='right' caption='[[5fyn]], [[Resolution|resolution]] 15.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5fyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FYN FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fyn OCA], [http://pdbe.org/5fyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fyn RCSB], [http://www.ebi.ac.uk/pdbsum/5fyn PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Hantaviruses, a geographically diverse group of zoonotic pathogens, initiate cell infection through the concerted action of Gn and Gc viral surface glycoproteins. Here, we describe the high-resolution crystal structure of the antigenic ectodomain of Gn from Puumala hantavirus (PUUV), a causative agent of hemorrhagic fever with renal syndrome. Fitting of PUUV Gn into an electron cryomicroscopy reconstruction of intact Gn-Gc spike complexes from the closely related but non-pathogenic Tula hantavirus localized Gn tetramers to the membrane-distal surface of the virion. The accuracy of the fitting was corroborated by epitope mapping and genetic analysis of available PUUV sequences. Interestingly, Gn exhibits greater non-synonymous sequence diversity than the less accessible Gc, supporting a role of the host humoral immune response in exerting selective pressure on the virus surface. The fold of PUUV Gn is likely to be widely conserved across hantaviruses. | ||
| - | + | A Molecular-Level Account of the Antigenic Hantaviral Surface.,Li S, Rissanen I, Zeltina A, Hepojoki J, Raghwani J, Harlos K, Pybus OG, Huiskonen JT, Bowden TA Cell Rep. 2016 May 3;15(5):959-67. doi: 10.1016/j.celrep.2016.03.082. Epub 2016, Apr 21. PMID:27117403<ref>PMID:27117403</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5fyn" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bowden, T A]] | ||
| + | [[Category: Harlos, K]] | ||
| + | [[Category: Hepojoki, J]] | ||
| + | [[Category: Huiskonen, J T]] | ||
[[Category: Li, S]] | [[Category: Li, S]] | ||
| + | [[Category: Pybus, O G]] | ||
[[Category: Raghwani, J]] | [[Category: Raghwani, J]] | ||
| - | [[Category: Pybus, O.G]] | ||
| - | [[Category: Zeltina, A]] | ||
[[Category: Rissanen, I]] | [[Category: Rissanen, I]] | ||
| - | [[Category: | + | [[Category: Zeltina, A]] |
| - | [[Category: | + | [[Category: Bunyavirus]] |
| - | [[Category: | + | [[Category: Glycoprotein]] |
| - | [[Category: | + | [[Category: Hantavirus]] |
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Receptor binding]] | ||
| + | [[Category: Tula virus]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 15:23, 20 June 2016
Sub-tomogram averaging of Tula virus glycoprotein spike
| |||||||||||
