This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5e24
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the Su(H)-Hairless-DNA Repressor Complex== | |
| - | + | <StructureSection load='5e24' size='340' side='right' caption='[[5e24]], [[Resolution|resolution]] 2.14Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5e24]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E24 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MTT:MALTOTETRAOSE'>MTT</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e24 OCA], [http://pdbe.org/5e24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e24 RCSB], [http://www.ebi.ac.uk/pdbsum/5e24 PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity). [[http://www.uniprot.org/uniprot/SUH_DROME SUH_DROME]] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Required for neurogenesis in imaginal disks. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Required for transcription of Sim. Also functions independently of Notch pathway, in the development of the bristle sensory organ precursor cell.<ref>PMID:10673509</ref> <ref>PMID:12642500</ref> <ref>PMID:7813798</ref> [[http://www.uniprot.org/uniprot/HLES_DROME HLES_DROME]] Is a potent antagonist of neurogenic gene activity during sensory organ development. The expression of distinct cell fates by the trichogen (shaft) / tormogen (socket) sister cell pair depends on the level of H activity. A certain threshold level of H activity is required, below which both sister cells adopt the tormogen fate.<ref>PMID:1419850</ref> <ref>PMID:1516831</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kovall, R A]] | ||
[[Category: Yuan, Z]] | [[Category: Yuan, Z]] | ||
| - | [[Category: | + | [[Category: Csl]] |
| + | [[Category: Hairless]] | ||
| + | [[Category: Notch signaling]] | ||
| + | [[Category: Suppressor of hairless]] | ||
| + | [[Category: Transport-dna binding-dna complex]] | ||
Revision as of 22:24, 20 June 2016
Structure of the Su(H)-Hairless-DNA Repressor Complex
| |||||||||||
