5i22
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Amphiphysin SH3 in complex with Chikungunya virus nsP3 peptide== | |
| - | + | <StructureSection load='5i22' size='340' side='right' caption='[[5i22]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5i22]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I22 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i22 OCA], [http://pdbe.org/5i22 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i22 RCSB], [http://www.ebi.ac.uk/pdbsum/5i22 PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] Defects in BIN1 are the cause of centronuclear myopathy type 2 (CNM2) [MIM:[http://omim.org/entry/255200 255200]]. A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.<ref>PMID:17676042</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN]] May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aitio, O]] | ||
[[Category: Hellman, M]] | [[Category: Hellman, M]] | ||
| + | [[Category: Permi, P]] | ||
| + | [[Category: Saksela, K]] | ||
[[Category: Tossavainen, H]] | [[Category: Tossavainen, H]] | ||
| - | [[Category: | + | [[Category: Function: protein binding chikungunya virus nsp3 peptide]] |
| - | [[Category: | + | [[Category: Function: viral replication]] |
| - | [[Category: | + | [[Category: Sh3 domain]] |
| + | [[Category: Transcription]] | ||
Revision as of 22:25, 20 June 2016
Amphiphysin SH3 in complex with Chikungunya virus nsP3 peptide
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