This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5b40
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | The | + | ==The nucleosome structure containing H2B-K120 and H4-K31 monoubiquitinations== |
| - | + | <StructureSection load='5b40' size='340' side='right' caption='[[5b40]], [[Resolution|resolution]] 3.33Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5b40]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B40 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b40 OCA], [http://pdbe.org/5b40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b40 RCSB], [http://www.ebi.ac.uk/pdbsum/5b40 PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Horikoshi, N]] | ||
| + | [[Category: Kurumizaka, H]] | ||
| + | [[Category: Machida, S]] | ||
| + | [[Category: Nishiyama, Y]] | ||
| + | [[Category: Sekine, S]] | ||
| + | [[Category: Chromatin]] | ||
| + | [[Category: Histone modification]] | ||
| + | [[Category: Nucleosome]] | ||
| + | [[Category: Structural protein-dna complex]] | ||
| + | [[Category: Ubiquitin]] | ||
Revision as of 23:22, 23 June 2016
The nucleosome structure containing H2B-K120 and H4-K31 monoubiquitinations
| |||||||||||
