5c5b
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Human APPL BAR-PH Heterodimer== | |
| - | + | <StructureSection load='5c5b' size='340' side='right' caption='[[5c5b]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5c5b]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C5B FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5b OCA], [http://pdbe.org/5c5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c5b RCSB], [http://www.ebi.ac.uk/pdbsum/5c5b PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/DP13B_HUMAN DP13B_HUMAN]] A chromosomal aberration involving APPL2/DIP13B is found in patients with chromosome 22q13.3 deletion syndrome. Translocation t(12;22)(q24.1;q13.3) with SHANK3/PSAP2. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref> [[http://www.uniprot.org/uniprot/DP13B_HUMAN DP13B_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:15016378</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chen, B]] | ||
| + | [[Category: Chen, Y J]] | ||
| + | [[Category: Heterodimer]] | ||
| + | [[Category: Protein transport]] | ||
Revision as of 23:22, 23 June 2016
Crystal Structure of Human APPL BAR-PH Heterodimer
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