5f91
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator (N-(5-(azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide)== | |
| - | + | <StructureSection load='5f91' size='340' side='right' caption='[[5f91]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5f91]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F91 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5WJ:~{N}-[5-(AZEPAN-1-YLSULFONYL)-2-METHOXY-PHENYL]-2-(4-OXIDANYLIDENE-3~{H}-PHTHALAZIN-1-YL)ETHANAMIDE'>5WJ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f92|5f92]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f91 OCA], [http://pdbe.org/5f91 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f91 RCSB], [http://www.ebi.ac.uk/pdbsum/5f91 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FUMC_MYCTO FUMC_MYCTO]] Catalyzes the reversible addition of water to fumarate to give L-malate. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fumarate hydratase]] | ||
| + | [[Category: Abell, C]] | ||
| + | [[Category: Barry, C E]] | ||
| + | [[Category: Boshoff, H I]] | ||
| + | [[Category: Fischer, G]] | ||
| + | [[Category: Hyvonen, M]] | ||
| + | [[Category: Kasbekar, M]] | ||
| + | [[Category: Mott, B T]] | ||
| + | [[Category: Thomas, C J]] | ||
| + | [[Category: Yasgar, A]] | ||
| + | [[Category: Allostery]] | ||
| + | [[Category: Hydratase]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Lyase-lyase inhibitor complex]] | ||
| + | [[Category: Metabolism]] | ||
| + | [[Category: Modulation]] | ||
| + | [[Category: Tuberculosis]] | ||
Revision as of 23:25, 23 June 2016
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator (N-(5-(azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide)
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