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5jd0

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'''Unreleased structure'''
 
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The entry 5jd0 is ON HOLD until Paper Publication
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==crystal structure of ARAP3 RhoGAP domain==
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<StructureSection load='5jd0' size='340' side='right' caption='[[5jd0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5jd0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JD0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JD0 FirstGlance]. <br>
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Description:
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jcp|5jcp]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jd0 OCA], [http://pdbe.org/5jd0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jd0 RCSB], [http://www.ebi.ac.uk/pdbsum/5jd0 PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ARAP3_HUMAN ARAP3_HUMAN]] Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.<ref>PMID:11804589</ref> <ref>PMID:15569923</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bao, H]]
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[[Category: Li, F]]
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[[Category: Shi, Y]]
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[[Category: Wu, J]]
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[[Category: Arap3]]
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[[Category: Rhogap]]
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[[Category: Signaling protein]]

Revision as of 23:28, 23 June 2016

crystal structure of ARAP3 RhoGAP domain

5jd0, resolution 2.30Å

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