5jka
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human JUNO (crystal form 1)== | |
| - | + | <StructureSection load='5jka' size='340' side='right' caption='[[5jka]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5jka]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JKA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jke|5jke]], [[5jkd|5jkd]], [[5jkc|5jkc]], [[5jkb|5jkb]], [[5jk9|5jk9]]</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jka OCA], [http://pdbe.org/5jka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jka RCSB], [http://www.ebi.ac.uk/pdbsum/5jka PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/JUNO_HUMAN JUNO_HUMAN]] Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.[UniProtKB:Q9EQF4] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Ishida, H]] | [[Category: Ishida, H]] | ||
[[Category: Ohto, U]] | [[Category: Ohto, U]] | ||
| + | [[Category: Shimizu, T]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Fertilization]] | ||
| + | [[Category: Izumo1]] | ||
| + | [[Category: Juno]] | ||
Revision as of 23:29, 23 June 2016
Crystal structure of human JUNO (crystal form 1)
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Categories: Ishida, H | Ohto, U | Shimizu, T | Cell adhesion | Fertilization | Izumo1 | Juno
