Phosphoenolpyruvate carboxykinase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_2olr| PDB=2olr | SIZE=350| SCENE= |right|CAPTION=ATP-driven E. coli PEPCK complex with ATP (stick model), CO2 and Mg+2 ion (green) [[2olr]] }} | ||
| + | <StructureSection load='1khf' size='350' side='right' caption='GTP-driven E. coli PEPCK complex with PEP (stick model), ethanediol, Na+ and Mn+2 ions (green) (PDB entry [[1khf]])' scene=''> | ||
| + | __TOC__ | ||
| + | == Function == | ||
'''Phosphoenolpyruvate carboxykinase''' (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP) and CO<sub>2</sub>. PEPCK is part of the gluconeogenesis pathway<ref>PMID:9242918</ref>. There are 3 types of PEPCK distinguished by the energy source of the reaction which can be GTP, ATP or diphosphate. | '''Phosphoenolpyruvate carboxykinase''' (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP) and CO<sub>2</sub>. PEPCK is part of the gluconeogenesis pathway<ref>PMID:9242918</ref>. There are 3 types of PEPCK distinguished by the energy source of the reaction which can be GTP, ATP or diphosphate. | ||
| + | == Structural highlights == | ||
| + | ''E. coli'' GTP-driven PEPCK active site is located in a pocket at the enzyme surface<ref>PMID:11851336</ref>. | ||
| + | |||
| + | </StructureSection> | ||
== 3D Structures of PEPCK == | == 3D Structures of PEPCK == | ||
Revision as of 08:19, 27 June 2016
| |||||||||||
3D Structures of PEPCK
Updated on 27-June-2016
References
- ↑ Hanson RW, Reshef L. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu Rev Biochem. 1997;66:581-611. PMID:9242918 doi:http://dx.doi.org/10.1146/annurev.biochem.66.1.581
- ↑ Dunten P, Belunis C, Crowther R, Hollfelder K, Kammlott U, Levin W, Michel H, Ramsey GB, Swain A, Weber D, Wertheimer SJ. Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. J Mol Biol. 2002 Feb 15;316(2):257-64. PMID:11851336 doi:http://dx.doi.org/10.1006/jmbi.2001.5364
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
