Phosphoribosyltransferase

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== Function ==
== Function ==
'''Phosphoribosyltransferase''' (PRT) are transferases which belong to several classes: <br />
'''Phosphoribosyltransferase''' (PRT) are transferases which belong to several classes: <br />
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1. '''Hypoxanthine-guanine PRT''' (HPRT). HPRT is part of the purine biosynthesis and catalyzes the formation of GMP from guanine, xanthosine monophosphate from xanthosine and of inosine monophosphate from hypoxanthine. <br />
+
1. '''Hypoxanthine-guanine PRT''' (HPRT). HPRT is part of the purine biosynthesis and catalyzes the formation of GMP from guanine, xanthosine monophosphate from xanthosine and of inosine monophosphate from hypoxanthine<ref>PMID:1487231</ref>. <br />
-
2. '''Orotate PRT''' (OPRT). OPRT is part of the pyrimidine biosynthesis and catalyzes the formation of orotidine 5’-monophosphate (OMP) from orotate and phosphoribosyl pyrophosphate (PRPP). <br />
+
2. '''Orotate PRT''' (OPRT). OPRT is part of the pyrimidine biosynthesis and catalyzes the formation of orotidine 5’-monophosphate (OMP) from orotate and phosphoribosyl pyrophosphate (PRPP)<ref>PMID:18020427</ref>. <br />
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3. '''Quinolinic acid PRT''' (QAPRT ). QAPRT is a degrading enzyme found in the brain. <br />
+
3. '''Quinolinic acid PRT''' (QAPRT ). QAPRT is a degrading enzyme found in the brain<ref>PMID:3159462</ref>. <br />
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4. '''Uracil PRT''' (UPRT). UPRT catalyzes the formation of UMP from uracil and PRPP. Adenine PRT (APRT). APRT catalyzes the formation of AMP from adenine and PRPP. <br />
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4. '''Uracil PRT''' (UPRT). UPRT catalyzes the formation of UMP from uracil and PRPP. Adenine PRT (APRT). APRT catalyzes the formation of AMP from adenine and PRPP<ref>PMID:9247925</ref>. <br />
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5. '''Nicotinate nucleotide dimethylbenzimidazole PRT''' (NN:DBI PRT). NN:DBI PRT is part of riboflavin, porphyrin and chlorophyll biosynthesis. <br />
+
5. '''Nicotinate nucleotide dimethylbenzimidazole PRT''' (NN:DBI PRT). NN:DBI PRT is part of riboflavin, porphyrin and chlorophyll biosynthesis<ref>PMID:121011881</ref>. <br />
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6. '''Anthranilate PRT''' (ANPRT). ANPRT participates in phenylalanine, tyrosine and tryptophan biosynthesis and catalyzes the formation of anthraniline from phosphoribosyl anthranilate. <br />
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6. '''Anthranilate PRT''' (ANPRT). ANPRT participates in phenylalanine, tyrosine and tryptophan biosynthesis and catalyzes the formation of anthraniline from phosphoribosyl anthranilate<ref>PMID:23363292</ref>. <br />
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7. '''ATP PRT''' participates in histidine biosynthesis and catalyzes the formation of ATP from phosphoribosyl ATP and diphosphate. <br />
+
7. '''ATP PRT''' participates in histidine biosynthesis and catalyzes the formation of ATP from phosphoribosyl ATP and diphosphate<ref>PMID:22989207</ref>. <br />
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8. '''Nicotinate PRT''' (NIPRT). NIPRT catalyzes the formation of nicotinate from nicotinate ribonucleotide and diphosphate. <br />
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8. '''Nicotinate PRT''' (NIPRT). NIPRT catalyzes the formation of nicotinate from nicotinate ribonucleotide and diphosphate<ref>PMID:21742010</ref>. <br />
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9. '''Nicotinamide PRT''' (NMPRT). NMPRT catalyzes the formation of nicotinamide from nicotinamide ribonucleotide (NMN) and diphosphate.
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9. '''Nicotinamide PRT''' (NMPRT). NMPRT catalyzes the formation of nicotinamide from nicotinamide ribonucleotide (NMN) and diphosphate<ref>PMID:19149599</ref>.
== Disease ==
== Disease ==
 +
Mutations in HPRT are involved in Lesch-Nyhan syndrome and hereditary gout<ref>PMID:8112742</ref>.
 +
== Relevance ==
 +
NMPRT inhibition is a target in controlling inflammation disorders<ref>PMID:24171767</ref>.
</StructureSection>
</StructureSection>
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**[[3dkj]], [[3dkl]] - hNMPRT + benzamide + PRPP<BR />
**[[3dkj]], [[3dkl]] - hNMPRT + benzamide + PRPP<BR />
}}
}}
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== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:18, 30 June 2016

Template:STRUCTURE 3l0k

Contents

Function

Phosphoribosyltransferase (PRT) are transferases which belong to several classes:
1. Hypoxanthine-guanine PRT (HPRT). HPRT is part of the purine biosynthesis and catalyzes the formation of GMP from guanine, xanthosine monophosphate from xanthosine and of inosine monophosphate from hypoxanthine[1].
2. Orotate PRT (OPRT). OPRT is part of the pyrimidine biosynthesis and catalyzes the formation of orotidine 5’-monophosphate (OMP) from orotate and phosphoribosyl pyrophosphate (PRPP)[2].
3. Quinolinic acid PRT (QAPRT ). QAPRT is a degrading enzyme found in the brain[3].
4. Uracil PRT (UPRT). UPRT catalyzes the formation of UMP from uracil and PRPP. Adenine PRT (APRT). APRT catalyzes the formation of AMP from adenine and PRPP[4].
5. Nicotinate nucleotide dimethylbenzimidazole PRT (NN:DBI PRT). NN:DBI PRT is part of riboflavin, porphyrin and chlorophyll biosynthesis[5].
6. Anthranilate PRT (ANPRT). ANPRT participates in phenylalanine, tyrosine and tryptophan biosynthesis and catalyzes the formation of anthraniline from phosphoribosyl anthranilate[6].
7. ATP PRT participates in histidine biosynthesis and catalyzes the formation of ATP from phosphoribosyl ATP and diphosphate[7].
8. Nicotinate PRT (NIPRT). NIPRT catalyzes the formation of nicotinate from nicotinate ribonucleotide and diphosphate[8].
9. Nicotinamide PRT (NMPRT). NMPRT catalyzes the formation of nicotinamide from nicotinamide ribonucleotide (NMN) and diphosphate[9].

Disease

Mutations in HPRT are involved in Lesch-Nyhan syndrome and hereditary gout[10].

Relevance

NMPRT inhibition is a target in controlling inflammation disorders[11].

</StructureSection>

3D structures of phosphoribosyltransferase

Updated on 30-June-2016

References

  1. ↑ Sculley DG, Dawson PA, Emmerson BT, Gordon RB. A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. Hum Genet. 1992 Nov;90(3):195-207. PMID:1487231
  2. ↑ Gonzalez-Segura L, Witte JF, McClard RW, Hurley TD. Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase. Biochemistry. 2007 Dec 11;46(49):14075-86. Epub 2007 Nov 20. PMID:18020427 doi:10.1021/bi701023z
  3. ↑ Foster AC, Whetsell WO Jr, Bird ED, Schwarcz R. Quinolinic acid phosphoribosyltransferase in human and rat brain: activity in Huntington's disease and in quinolinate-lesioned rat striatum. Brain Res. 1985 Jun 17;336(2):207-14. PMID:3159462
  4. ↑ Carter D, Donald RG, Roos D, Ullman B. Expression, purification, and characterization of uracil phosphoribosyltransferase from Toxoplasma gondii. Mol Biochem Parasitol. 1997 Aug;87(2):137-44. PMID:9247925
  5. ↑ . PMID:121011881
  6. ↑ Castell A, Short FL, Evans GL, Cookson TV, Bulloch EM, Joseph DD, Lee CE, Parker EJ, Baker EN, Lott JS. Substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition. Biochemistry. 2013 Jan 30. PMID:23363292 doi:http://dx.doi.org/10.1021/bi301387m
  7. ↑ Pedreno S, Pisco JP, Larrouy-Maumus G, Kelly G, de Carvalho LP. Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase. Biochemistry. 2012 Oct 9;51(40):8027-38. doi: 10.1021/bi300808b. Epub 2012 Sep, 27. PMID:22989207 doi:http://dx.doi.org/10.1021/bi300808b
  8. ↑ Galassi L, Di Stefano M, Brunetti L, Orsomando G, Amici A, Ruggieri S, Magni G. Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis. Biochimie. 2012 Feb;94(2):300-9. doi: 10.1016/j.biochi.2011.06.033. Epub 2011 Jul, 3. PMID:21742010 doi:http://dx.doi.org/10.1016/j.biochi.2011.06.033
  9. ↑ Imai S. Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases. Curr Pharm Des. 2009;15(1):20-8. PMID:19149599
  10. ↑ Tohyama J, Nanba E, Ohno K. Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency: identification of point mutations in Japanese patients with Lesch-Nyhan syndrome and hereditary gout and their permanent expression in an HPRT-deficient mouse cell line. Hum Genet. 1994 Feb;93(2):175-81. PMID:8112742
  11. ↑ Montecucco F, Cea M, Cagnetta A, Damonte P, Nahimana A, Ballestrero A, Del Rio A, Bruzzone S, Nencioni A. Nicotinamide phosphoribosyltransferase as a target in inflammation- related disorders. Curr Top Med Chem. 2013;13(23):2930-8. PMID:24171767

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