Phosphoserine aminotransferase
From Proteopedia
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== Function == | == Function == | ||
| - | '''Phosphoserine aminotransferase''' (PSAT) catalyzes the reversible conversion of phosphoserine and oxoglutarate to produce glutamate and 3-phosphonooxypyruvate. PSAT is part of the phosphoserine biosynthesis. Pyridoxal phosphate (vitamin B6, PLP) is a cofactor of PAT. | + | '''Phosphoserine aminotransferase''' (PSAT) catalyzes the reversible conversion of phosphoserine and oxoglutarate to produce glutamate and 3-phosphonooxypyruvate. PSAT is part of the phosphoserine biosynthesis<ref>PMID:10637769</ref>. Pyridoxal phosphate (vitamin B6, PLP) is a cofactor of PAT. |
== Relevance == | == Relevance == | ||
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**[[4xk1]] - PSAT + PLP + glutamate – ''Pseudomonas aeruginosa''<br /> | **[[4xk1]] - PSAT + PLP + glutamate – ''Pseudomonas aeruginosa''<br /> | ||
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| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:48, 30 June 2016
Contents |
Function
Phosphoserine aminotransferase (PSAT) catalyzes the reversible conversion of phosphoserine and oxoglutarate to produce glutamate and 3-phosphonooxypyruvate. PSAT is part of the phosphoserine biosynthesis[1]. Pyridoxal phosphate (vitamin B6, PLP) is a cofactor of PAT.
Relevance
PSAT is over-expressed in colon tumors and its inhibition is being tested as drug treatment.
3D structures of phosphoserine aminotransferase
Updated on 30-June-2016
References
- ↑ Basurko MJ, Marche M, Darriet M, Cassaigne A. Phosphoserine aminotransferase, the second step-catalyzing enzyme for serine biosynthesis. IUBMB Life. 1999 Nov;48(5):525-9. PMID:10637769 doi:http://dx.doi.org/10.1080/713803557
