Phosphoserine phosphatase
From Proteopedia
(Difference between revisions)
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| - | <applet load='1l8o' size='400' frame='true' align='right' caption=' | + | <applet load='1l8o' size='400' frame='true' align='right' caption='Human phosphoserine phosphatase dimer complex with serene and phosphate[[1l8o]]' /> |
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== Structural highlights == | == Structural highlights == | ||
| - | + | The human PSP overall structure contains a large core domain and a smaller 4-helix bundle domain. The active site is located in a cleft between the 2 domains<ref>PMID:12213811</ref>. | |
</StructureSection> | </StructureSection> | ||
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**[[1l7o]] – MjPSP (mutant) + Zn – ''Methanocaldococcus jannaschi''i<br /> | **[[1l7o]] – MjPSP (mutant) + Zn – ''Methanocaldococcus jannaschi''i<br /> | ||
**[[1l8l]] – hPSP (mutant) + phosphono-propionic acid – human<br /> | **[[1l8l]] – hPSP (mutant) + phosphono-propionic acid – human<br /> | ||
| - | **[[1l8o]] – hPSP (mutant) + PO4<br /> | ||
**[[1nnl]] – hPSP + Ca<br /> | **[[1nnl]] – hPSP + Ca<br /> | ||
**[[3w40]], [[3w41]] – BsPSP + Mg<br /> | **[[3w40]], [[3w41]] – BsPSP + Mg<br /> | ||
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*Phosphoserine phosphatase ternary complex | *Phosphoserine phosphatase ternary complex | ||
| + | **[[1l8o]] – hPSP (mutant) + serine + PO4<br /> | ||
**[[1f5s]], [[1j97]], [[1l7m]] – MjPSP + PO4 + Mg<br /> | **[[1f5s]], [[1j97]], [[1l7m]] – MjPSP + PO4 + Mg<br /> | ||
**[[1l7n]] – MjPSP + AlF4 + Mg<br /> | **[[1l7n]] – MjPSP + AlF4 + Mg<br /> | ||
Revision as of 07:34, 3 July 2016
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Contents |
Function
Phosphoserine phosphatase (PSP) catalyzes the dephosphorylation of phosphoserine to produce serine and phosphate. This is the last reaction in serine biosynthesis. PSP is part of the glycine, serine and threonine metabolism[1]. Mg+2 ion is a cofactor of PSP.
Disease
Mutations of PSP were found in patients with Williams syndrome[2].
Structural highlights
The human PSP overall structure contains a large core domain and a smaller 4-helix bundle domain. The active site is located in a cleft between the 2 domains[3].
</StructureSection>
3D structures of phosphoserine phosphatase
Updated on 03-July-2016
References
- ↑ NEUHAUS FC, BYRNE WL. Metabolism of phosphoserine. II. Purification and properties of O-phosphoserine phosphatase. J Biol Chem. 1959 Jan;234(1):113-21. PMID:13610904
- ↑ Jaeken J, Detheux M, Fryns JP, Collet JF, Alliet P, Van Schaftingen E. Phosphoserine phosphatase deficiency in a patient with Williams syndrome. J Med Genet. 1997 Jul;34(7):594-6. PMID:9222972
- ↑ Kim HY, Heo YS, Kim JH, Park MH, Moon J, Kim E, Kwon D, Yoon J, Shin D, Jeong EJ, Park SY, Lee TG, Jeon YH, Ro S, Cho JM, Hwang KY. Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase. J Biol Chem. 2002 Nov 29;277(48):46651-8. Epub 2002 Sep 3. PMID:12213811 doi:10.1074/jbc.M204866200
