Phosphoserine phosphatase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
<applet load='1l8o' size='400' frame='true' align='right' caption='Human phosphoserine phosphatase dimer complex with serene and phosphate[[1l8o]]' />
+
<applet load='1l8o' size='400' frame='true' align='right' caption='Human phosphoserine phosphatase dimer complex with serine and phosphate[[1l8o]]' />
Line 10: Line 10:
== Structural highlights ==
== Structural highlights ==
The human PSP overall structure contains a large core domain and a smaller 4-helix bundle domain. The active site is located in a cleft between the 2 domains<ref>PMID:12213811</ref>.
The human PSP overall structure contains a large core domain and a smaller 4-helix bundle domain. The active site is located in a cleft between the 2 domains<ref>PMID:12213811</ref>.
- 
-
</StructureSection>
 
==3D structures of phosphoserine phosphatase==
==3D structures of phosphoserine phosphatase==

Revision as of 07:35, 3 July 2016

Human phosphoserine phosphatase dimer complex with serine and phosphate1l8o

Drag the structure with the mouse to rotate


Contents

Function

Phosphoserine phosphatase (PSP) catalyzes the dephosphorylation of phosphoserine to produce serine and phosphate. This is the last reaction in serine biosynthesis. PSP is part of the glycine, serine and threonine metabolism[1]. Mg+2 ion is a cofactor of PSP.

Disease

Mutations of PSP were found in patients with Williams syndrome[2].

Structural highlights

The human PSP overall structure contains a large core domain and a smaller 4-helix bundle domain. The active site is located in a cleft between the 2 domains[3].

3D structures of phosphoserine phosphatase

Updated on 03-July-2016

References

  1. ↑ NEUHAUS FC, BYRNE WL. Metabolism of phosphoserine. II. Purification and properties of O-phosphoserine phosphatase. J Biol Chem. 1959 Jan;234(1):113-21. PMID:13610904
  2. ↑ Jaeken J, Detheux M, Fryns JP, Collet JF, Alliet P, Van Schaftingen E. Phosphoserine phosphatase deficiency in a patient with Williams syndrome. J Med Genet. 1997 Jul;34(7):594-6. PMID:9222972
  3. ↑ Kim HY, Heo YS, Kim JH, Park MH, Moon J, Kim E, Kwon D, Yoon J, Shin D, Jeong EJ, Park SY, Lee TG, Jeon YH, Ro S, Cho JM, Hwang KY. Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase. J Biol Chem. 2002 Nov 29;277(48):46651-8. Epub 2002 Sep 3. PMID:12213811 doi:10.1074/jbc.M204866200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Phosphoserine_phosphatase"
Personal tools