Phosphotriesterase
From Proteopedia
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{{STRUCTURE_3cak| PDB=3cak | SIZE=400| SCENE= |right|CAPTION=Phosphotriesterase dimer complex with reaction product ethyl phosphate and Co+2 ion (pink), [[3cak]] }} | {{STRUCTURE_3cak| PDB=3cak | SIZE=400| SCENE= |right|CAPTION=Phosphotriesterase dimer complex with reaction product ethyl phosphate and Co+2 ion (pink), [[3cak]] }} | ||
| - | + | == Function == | |
| - | + | '''Phosphotriesterase''' or '''aryldialkylphosphatase''' (PTE) catalyzes the conversion of aryl dialkyl phosphate to dialkyl phosphate and aryl alcohol<ref>PMID:15790580</ref>. | |
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| - | + | == Relevance == | |
| - | + | PTE has no known natural substrate but has potential in detoxification of organophosphates poisons lethal effects. PTE can detoxify the insecticide paraoxon and the chemical warfare agent sarin<ref>PMID:26274608</ref>. | |
| - | '''Phosphotriesterase''' or '''aryldialkylphosphatase''' (PTE) catalyzes the conversion of aryl dialkyl phosphate to dialkyl phosphate and aryl alcohol. PTE has no known natural substrate but has potential in detoxification of organophosphates poisons lethal effects. PTE can detoxify the insecticide paraoxon and the chemical warfare agent sarin. | + | |
==3D structures of phosphotriesterase== | ==3D structures of phosphotriesterase== | ||
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| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:55, 3 July 2016
Contents |
Function
Phosphotriesterase or aryldialkylphosphatase (PTE) catalyzes the conversion of aryl dialkyl phosphate to dialkyl phosphate and aryl alcohol[1].
Relevance
PTE has no known natural substrate but has potential in detoxification of organophosphates poisons lethal effects. PTE can detoxify the insecticide paraoxon and the chemical warfare agent sarin[2].
3D structures of phosphotriesterase
Updated on 03-July-2016
References
- ↑ Roodveldt C, Tawfik DS. Directed evolution of phosphotriesterase from Pseudomonas diminuta for heterologous expression in Escherichia coli results in stabilization of the metal-free state. Protein Eng Des Sel. 2005 Jan;18(1):51-8. PMID:15790580 doi:http://dx.doi.org/10.1093/protein/gzi005
- ↑ Bigley AN, Mabanglo MF, Harvey SP, Raushel FM. Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR. Biochemistry. 2015 Aug 25. PMID:26274608 doi:http://dx.doi.org/10.1021/acs.biochem.5b00629
