Poly (ADP-ribose) glycohydrolase
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''Poly (ADP-ribose) glycohydrolase''' (PARG) hydrolizes the ribose-ribose bonds in poly (ADP-ribose). Poly (ADP-ribose) are synthesized after DNA damage. PARG acts as both endo- and exoglycosidase and releases poly (ADP-ribose) of different lengths including monomers. | + | '''Poly (ADP-ribose) glycohydrolase''' (PARG) hydrolizes the ribose-ribose bonds in poly (ADP-ribose). Poly (ADP-ribose) are synthesized after DNA damage. PARG acts as both endo- and exoglycosidase and releases poly (ADP-ribose) of different lengths including monomers<ref>PMID:11376691</ref>. |
== Disease == | == Disease == | ||
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== Relevance == | == Relevance == | ||
| - | PARG deficiency leads to cell death. | + | PARG deficiency leads to cell death. Over-activation of PARP due to oxidative stress culminates in cell dysfunction and necrosis. PARP inhibitors have anti-inflammatory effect<ref>PMID:12223530</ref>. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 09:45, 5 July 2016
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3D Structures of poly (ADP-ribose) glycohydrolase
Updated on 05-July-2016
References
- ↑ Herceg Z, Wang ZQ. Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. Mutat Res. 2001 Jun 2;477(1-2):97-110. PMID:11376691
- ↑ Virag L, Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev. 2002 Sep;54(3):375-429. PMID:12223530
