Poly (ADP-ribose) polymerase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ||
{{STRUCTURE_3l3l| PDB=3l3l | SIZE=400| SCENE= |right|CAPTION=Poly (ADP-ribose) polymerase complex with inhibitor [[3l3l]] }} | {{STRUCTURE_3l3l| PDB=3l3l | SIZE=400| SCENE= |right|CAPTION=Poly (ADP-ribose) polymerase complex with inhibitor [[3l3l]] }} | ||
| - | + | == Function == | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
[[Poly (ADP-ribose) polymerase]] '''(PARP)''' is involved in DNA repair and programmed cell death. The PARP family contains 17 members. PARP is composed of 4 domains. Among them are the N terminal DNA-binding domain which contains 2 zinc fingers; auto modification domain which contains a WGR-rich domain; C terminal which includes the catalytic domain (or PARP domain). PARP-10 contains a RNA recognition motif (RRM). '''Tankyrase (Tank)''' is a PARP which contains ankyrin repeats (a 33-residue repeat with 2 α-helices separated by loops). | [[Poly (ADP-ribose) polymerase]] '''(PARP)''' is involved in DNA repair and programmed cell death. The PARP family contains 17 members. PARP is composed of 4 domains. Among them are the N terminal DNA-binding domain which contains 2 zinc fingers; auto modification domain which contains a WGR-rich domain; C terminal which includes the catalytic domain (or PARP domain). PARP-10 contains a RNA recognition motif (RRM). '''Tankyrase (Tank)''' is a PARP which contains ankyrin repeats (a 33-residue repeat with 2 α-helices separated by loops). | ||
Revision as of 10:02, 5 July 2016
Function
Poly (ADP-ribose) polymerase (PARP) is involved in DNA repair and programmed cell death. The PARP family contains 17 members. PARP is composed of 4 domains. Among them are the N terminal DNA-binding domain which contains 2 zinc fingers; auto modification domain which contains a WGR-rich domain; C terminal which includes the catalytic domain (or PARP domain). PARP-10 contains a RNA recognition motif (RRM). Tankyrase (Tank) is a PARP which contains ankyrin repeats (a 33-residue repeat with 2 α-helices separated by loops).
3D Structures of Poly (ADP-ribose) polymerase
Updated on 05-July-2016
