Poly (ADP-ribose) polymerase
From Proteopedia
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**[[2rf5]] - hTank 1 catalytic domain (mutant)<br /> | **[[2rf5]] - hTank 1 catalytic domain (mutant)<br /> | ||
**[[3udd]], [[3uh2]], [[3uh4]], [[4dvi]], [[4i9i]], [[4k4e]], [[4k4f]], [[4krs]], [[4li6]], [[4li7]], [[4li8]], [[4msg]], [[4msk]], [[4mt9]], [[4n3r]], [[4n4v]], [[4oa7]], [[4w5s]], [[4w6e]] - hTank 1 catalytic domain + inhibitor<br /> | **[[3udd]], [[3uh2]], [[3uh4]], [[4dvi]], [[4i9i]], [[4k4e]], [[4k4f]], [[4krs]], [[4li6]], [[4li7]], [[4li8]], [[4msg]], [[4msk]], [[4mt9]], [[4n3r]], [[4n4v]], [[4oa7]], [[4w5s]], [[4w6e]] - hTank 1 catalytic domain + inhibitor<br /> | ||
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*Tankyrase 2 | *Tankyrase 2 | ||
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**[[4hkk]], [[4hkn]], [[4hl5]], [[4hlf]], [[4hlg]], [[4hlh]], [[4hlk]], [[4hlm]], [[4hmh]], [[4kzl]], [[4kzq]], [[4kzu]], [[4l09]], [[4l0b]], [[4l0i]], [[4l0s]], [[4l0t]], [[4l0v]], [[4l10]], [[4l2f]], [[4l2g]], [[4l2k]], [[4l31]], [[4l32]], [[4l33]], [[4l34]] - hTank 2 catalytic and C terminal domains + inhibitor<br /> | **[[4hkk]], [[4hkn]], [[4hl5]], [[4hlf]], [[4hlg]], [[4hlh]], [[4hlk]], [[4hlm]], [[4hmh]], [[4kzl]], [[4kzq]], [[4kzu]], [[4l09]], [[4l0b]], [[4l0i]], [[4l0s]], [[4l0t]], [[4l0v]], [[4l10]], [[4l2f]], [[4l2g]], [[4l2k]], [[4l31]], [[4l32]], [[4l33]], [[4l34]] - hTank 2 catalytic and C terminal domains + inhibitor<br /> | ||
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| + | == References == | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:16, 5 July 2016
Function
Poly (ADP-ribose) polymerase (PARP) is involved in DNA repair and programmed cell death. The PARP family contains 17 members. PARP is composed of 4 domains. Among them are the N terminal DNA-binding domain which contains 2 zinc fingers; auto modification domain which contains a WGR-rich domain; C terminal which includes the catalytic domain (or PARP domain).
- PARP-1 and PARP-2 recognize and is activated by DNA breaks[1], [2].
- PARP-3 prevents from extensive end resection to promote double-strand DNA repair [3].
- PARP-10 contains a RNA recognition motif (RRM).
- Tankyrase (Tank) is a PARP which contains ankyrin repeats (a 33-residue repeat with 2 α-helices separated by loops).
3D Structures of Poly (ADP-ribose) polymerase
Updated on 05-July-2016
References
- ↑ Shall S, de Murcia G. Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? Mutat Res. 2000 Jun 30;460(1):1-15. PMID:10856830
- ↑ Dantzer F, Giraud-Panis MJ, Jaco I, Ame JC, Schultz I, Blasco M, Koering CE, Gilson E, Menissier-de Murcia J, de Murcia G, Schreiber V. Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2. Mol Cell Biol. 2004 Feb;24(4):1595-607. PMID:14749375
- ↑ Beck C, Robert I, Reina-San-Martin B, Schreiber V, Dantzer F. Poly(ADP-ribose) polymerases in double-strand break repair: focus on PARP1, PARP2 and PARP3. Exp Cell Res. 2014 Nov 15;329(1):18-25. doi: 10.1016/j.yexcr.2014.07.003. Epub, 2014 Jul 10. PMID:25017100 doi:http://dx.doi.org/10.1016/j.yexcr.2014.07.003
