Porphobilinogen synthase
From Proteopedia
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| + | <StructureSection load='1h7o' size='350' side='right' caption='Yeast porphobilinogen synthase dimer with Zn+2 (small grey) complex with porphobilinogen and sulfate (PDB entry [[1h7o]])' scene=''> | ||
== Function == | == Function == | ||
| - | '''Porphobilinogen synthase''' (PBS) catalyzes the formation of porphobilinogen (PBG) from 2 molecules of | + | '''Porphobilinogen synthase''' (PBS) catalyzes the formation of porphobilinogen (PBG) from 2 molecules of aminolaevulinic acid (ALA). PBS participates in porphyrin biosynthesis<ref>PMID:15381398</ref>. Levulinic acid (LA) is an inhibitor of PBS. Porphyrin is the precursor of hemes, chlorophyll and vitamin B12. |
== Disease == | == Disease == | ||
PBS deficiency can be caused by lead and other heavy metal poisoning<ref>PMID:7104498</ref>. | PBS deficiency can be caused by lead and other heavy metal poisoning<ref>PMID:7104498</ref>. | ||
| - | ===3D structures of porphobilinogen synthase | + | == Structural highlights == |
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| + | </StructureSection> | ||
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| + | ==3D structures of porphobilinogen synthase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
Revision as of 08:24, 10 July 2016
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3D structures of porphobilinogen synthase
Updated on 10-July-2016
References
- ↑ Jaffe EK. The porphobilinogen synthase catalyzed reaction mechanism. Bioorg Chem. 2004 Oct;32(5):316-25. PMID:15381398 doi:http://dx.doi.org/10.1016/j.bioorg.2004.05.010
- ↑ Doss M, Muller WA. Acute lead poisoning in inherited porphobilinogen synthase (delta-aminolevulinic acid dehydrase) deficiency. Blut. 1982 Aug;45(2):131-9. PMID:7104498
