Pregnane X receptor

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<StructureSection load='1skx' size='350' side='right' caption='Structure of human pregnane X receptor LBD complex with antibiotic rifampicin (PDB entry [[1skx]])' scene=''>
<StructureSection load='1skx' size='350' side='right' caption='Structure of human pregnane X receptor LBD complex with antibiotic rifampicin (PDB entry [[1skx]])' scene=''>
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== Function ==
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'''Pregnane X receptor''' (PXR) is a [[Nuclear receptor]] which senses the presence of toxic substances and regulates the expression of proteins which are involved in detoxificaton. PXR is activated by a large range of steroids, antibiotics, bile acids and many herbal compounds. Thus it is a generalized sensor of hydrophobic toxins. When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA. PXR, similar to other nuclear receptors contains a ligand-binding domain (LBD) and DNA-binding domain (DBD)<ref>PMID:12372848</ref>.
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'''Pregnane X receptor''' (PXR) is a [[Nuclear receptor]] which senses the presence of toxic substances and regulates the expression of proteins which are involved in detoxificaton. PXR is activated by a large range of steroids, antibiotics, bile acids and many herbal compounds. Thus it is a generalized sensor of hydrophobic toxins. When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA. PXR, similar to other nuclear receptors contains a ligand-binding domain (LBD) and DNA-binding domain (DBD).
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== Relevance ==
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PXR regulates the expression of milt-drug protein 1 and other proteins involved in drug metabolism thus affecting the efficacy of chemotherapeutics<ref>PMID:23237007</ref>.
</StructureSection>
</StructureSection>
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**[[3hvl]] – hPXR/steroid receptor coactivator + ligand<br />
**[[3hvl]] – hPXR/steroid receptor coactivator + ligand<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:17, 11 July 2016

Structure of human pregnane X receptor LBD complex with antibiotic rifampicin (PDB entry 1skx)

Drag the structure with the mouse to rotate

3D structures of pregnane X receptor

Updated on 11-July-2016

References

  1. ↑ Kliewer SA, Goodwin B, Willson TM. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev. 2002 Oct;23(5):687-702. PMID:12372848 doi:http://dx.doi.org/10.1210/er.2001-0038
  2. ↑ Koutsounas I, Theocharis S, Patsouris E, Giaginis C. Pregnane X receptor (PXR) at the crossroads of human metabolism and disease. Curr Drug Metab. 2013 Mar;14(3):341-50. PMID:23237007

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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