Preprotein translocase
From Proteopedia
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== Function == | == Function == | ||
'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor<ref>PMID:9489663</ref>. The translocase pathway contains:<br /> | '''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor<ref>PMID:9489663</ref>. The translocase pathway contains:<br /> | ||
| - | *'''SecB''' - a chaperone protein <br /> | + | *'''SecB''' - a chaperone protein<ref>PMID:9767586</ref> <br /> |
*'''SecY, SecE, SecG''' an integral membrane complex<br /> | *'''SecY, SecE, SecG''' an integral membrane complex<br /> | ||
*'''SecD, SecF''' - proteins promoting the release of the mature peptide into the periplasm<br /> | *'''SecD, SecF''' - proteins promoting the release of the mature peptide into the periplasm<br /> | ||
| - | *'''SecA''' - an ATPase unit.<br /> | + | *'''SecA''' - an ATPase unit<ref>PMID:10617931</ref>.<br /> |
For more details see [[SecA PBD motions]]. | For more details see [[SecA PBD motions]]. | ||
Revision as of 10:13, 11 July 2016
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3D structures of preprotein translocase
Updated on 11-July-2016
References
- ↑ Economou A. Bacterial preprotein translocase: mechanism and conformational dynamics of a processive enzyme. Mol Microbiol. 1998 Feb;27(3):511-8. PMID:9489663
- ↑ Fekkes P, de Wit JG, van der Wolk JP, Kimsey HH, Kumamoto CA, Driessen AJ. Preprotein transfer to the Escherichia coli translocase requires the co-operative binding of SecB and the signal sequence to SecA. Mol Microbiol. 1998 Sep;29(5):1179-90. PMID:9767586
- ↑ Schmidt MG, Kiser KB. SecA: the ubiquitous component of preprotein translocase in prokaryotes. Microbes Infect. 1999 Oct;1(12):993-1004. PMID:10617931
