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Preprotein translocase

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== Function ==
== Function ==
'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor<ref>PMID:9489663</ref>. The translocase pathway contains:<br />
'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor<ref>PMID:9489663</ref>. The translocase pathway contains:<br />
-
*'''SecB''' - a chaperone protein <br />
+
*'''SecB''' - a chaperone protein<ref>PMID:9767586</ref> <br />
*'''SecY, SecE, SecG''' an integral membrane complex<br />
*'''SecY, SecE, SecG''' an integral membrane complex<br />
*'''SecD, SecF''' - proteins promoting the release of the mature peptide into the periplasm<br />
*'''SecD, SecF''' - proteins promoting the release of the mature peptide into the periplasm<br />
-
*'''SecA''' - an ATPase unit.<br />
+
*'''SecA''' - an ATPase unit<ref>PMID:10617931</ref>.<br />
For more details see [[SecA PBD motions]].
For more details see [[SecA PBD motions]].

Revision as of 10:13, 11 July 2016

Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry 2yxr)

Drag the structure with the mouse to rotate

3D structures of preprotein translocase

Updated on 11-July-2016

References

  1. ↑ Economou A. Bacterial preprotein translocase: mechanism and conformational dynamics of a processive enzyme. Mol Microbiol. 1998 Feb;27(3):511-8. PMID:9489663
  2. ↑ Fekkes P, de Wit JG, van der Wolk JP, Kimsey HH, Kumamoto CA, Driessen AJ. Preprotein transfer to the Escherichia coli translocase requires the co-operative binding of SecB and the signal sequence to SecA. Mol Microbiol. 1998 Sep;29(5):1179-90. PMID:9767586
  3. ↑ Schmidt MG, Kiser KB. SecA: the ubiquitous component of preprotein translocase in prokaryotes. Microbes Infect. 1999 Oct;1(12):993-1004. PMID:10617931

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