Proliferating Cell Nuclear Antigen

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[[Image:1rwz.png|left|200px|thumb|Crystal Structure of Proliferating Cell Nuclear Antigen [[1rwz]]]]
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{{STRUCTURE_1vym| PDB=1vym | SIZE=400| SCENE= |right|CAPTION=Human proliferating cell nuclear antigen trimer [[1vym]] }}
{{STRUCTURE_1vym| PDB=1vym | SIZE=400| SCENE= |right|CAPTION=Human proliferating cell nuclear antigen trimer [[1vym]] }}
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== Function ==
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[[Proliferating Cell Nuclear Antigen]] (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells<ref>PMID:12829735</ref>.
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== Relevance ==
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PCNA is useful in the diagnosis of high-grade dysplasia<ref>PMID:8781908</ref>.
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[[Proliferating Cell Nuclear Antigen]] (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells. The images at the left and at the right correspond to one representative PCNA, ''i.e.'' the crystal structure of Proliferating Cell Nuclear Antigen from ''Archaeglobus fulgidus'' ([[1rwz]]).
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== 3D Structures of Proliferating Cell Nuclear Antigen ==
== 3D Structures of Proliferating Cell Nuclear Antigen ==
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**[[2zvw]], [[2zvv]] - PCNA + cyclin-dependent kinase inhibitor 1 - ''Arabidopsis thaliana''<br />
**[[2zvw]], [[2zvv]] - PCNA + cyclin-dependent kinase inhibitor 1 - ''Arabidopsis thaliana''<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:50, 12 July 2016

Template:STRUCTURE 1vym

Contents

Function

Proliferating Cell Nuclear Antigen (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells[1].

Relevance

PCNA is useful in the diagnosis of high-grade dysplasia[2].

3D Structures of Proliferating Cell Nuclear Antigen

Updated on 12-July-2016

References

  1. ↑ Maga G, Hubscher U. Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci. 2003 Aug 1;116(Pt 15):3051-60. PMID:12829735 doi:http://dx.doi.org/10.1242/jcs.00653
  2. ↑ Kullmann F, Fadaie M, Gross V, Knuchel R, Bocker T, Steinbach P, Scholmerich J, Ruschoff J. Expression of proliferating cell nuclear antigen (PCNA) and Ki-67 in dysplasia in inflammatory bowel disease. Eur J Gastroenterol Hepatol. 1996 Apr;8(4):371-9. PMID:8781908

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Michal Harel, Alexander Berchansky, Lukáš Cakl, Joel L. Sussman

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