1jmm
From Proteopedia
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|PDB= 1jmm |SIZE=350|CAPTION= <scene name='initialview01'>1jmm</scene>, resolution 2.40Å | |PDB= 1jmm |SIZE=350|CAPTION= <scene name='initialview01'>1jmm</scene>, resolution 2.40Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NA:SODIUM ION'>NA</scene> | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jmm OCA], [http://www.ebi.ac.uk/pdbsum/1jmm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jmm RCSB]</span> | ||
}} | }} | ||
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[[Category: Ogier, J.]] | [[Category: Ogier, J.]] | ||
[[Category: Troffer-Charlier, N.]] | [[Category: Troffer-Charlier, N.]] | ||
| - | [[Category: NA]] | ||
[[Category: antigen i/ii]] | [[Category: antigen i/ii]] | ||
[[Category: v-region]] | [[Category: v-region]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:35:48 2008'' |
Revision as of 18:35, 30 March 2008
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| , resolution 2.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the V-region of Streptococcus mutans antigen I/II
Overview
Antigens I/II are large multifunctional adhesins from oral viridans streptococci that exert immunomodulatory effects on human cells and play important roles in inflammatory disorders. Among them, Streptococcus mutans plays a major role in the initiation of dental caries. The structure of the V-region (SrV+, residues 464-840) of the antigen I/II of S. mutans has been determined using the multiwavelength anomalous diffraction phasing technique with seleno-methionine-substituted recombinant protein and subsequently refined at 2.4 A resolution. The crystal structure of SrV+ revealed a lectin-like fold that displays a putative preformed carbohydrate-binding site stabilized by a metal ion. Inhibition of this binding site may confer to humans a protection against dental caries and dissemination of the bacteria to extra-oral sites involved in life-threatening inflammatory diseases. This crystal structure constitutes a first step in understanding the structure-function relationship of antigens I/II and may help in delineating new preventive or therapeutic strategies against colonization of the host by oral streptococci.
About this Structure
1JMM is a Single protein structure of sequence from Streptococcus mutans. Full crystallographic information is available from OCA.
Reference
Crystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding site., Troffer-Charlier N, Ogier J, Moras D, Cavarelli J, J Mol Biol. 2002 Apr 19;318(1):179-88. PMID:12054777
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