1jnx
From Proteopedia
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|PDB= 1jnx |SIZE=350|CAPTION= <scene name='initialview01'>1jnx</scene>, resolution 2.5Å | |PDB= 1jnx |SIZE=350|CAPTION= <scene name='initialview01'>1jnx</scene>, resolution 2.5Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NI:NICKEL (II) ION'>NI</scene> | + | |LIGAND= <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= BRCA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= BRCA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1cdz|1CDZ]], [[1imo|1IMO]], [[1in1|1IN1]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnx OCA], [http://www.ebi.ac.uk/pdbsum/1jnx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jnx RCSB]</span> | ||
}} | }} | ||
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==Disease== | ==Disease== | ||
| - | Known | + | Known disease associated with this structure: Breast cancer-1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=113705 113705]], Breast-ovarian cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=113705 113705]], Ovarian cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=113705 113705]], Papillary serous carcinoma of the peritoneum OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=113705 113705]] |
==About this Structure== | ==About this Structure== | ||
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[[Category: Green, R.]] | [[Category: Green, R.]] | ||
[[Category: Williams, R S.]] | [[Category: Williams, R S.]] | ||
| - | [[Category: NI]] | ||
[[Category: brct]] | [[Category: brct]] | ||
[[Category: cancer]] | [[Category: cancer]] | ||
[[Category: gene expression]] | [[Category: gene expression]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:36:21 2008'' |
Revision as of 18:36, 30 March 2008
| |||||||
| , resolution 2.5Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | BRCA1 (Homo sapiens) | ||||||
| Related: | 1CDZ, 1IMO, 1IN1
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1
Contents |
Overview
The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we determine the crystal structure of the BRCT domain of human BRCA1 at 2.5 A resolution. The domain contains two BRCT repeats that adopt similar structures and are packed together in a head-to-tail arrangement. Cancer-causing missense mutations occur at the interface between the two repeats and destabilize the structure. The manner by which the two BRCT repeats interact in BRCA1 may represent a general mode of interaction between homologous domains within proteins that interact to regulate the cellular response to DNA damage. The structure provides a basis to predict the structural consequences of uncharacterized BRCA1 mutations.
Disease
Known disease associated with this structure: Breast cancer-1 OMIM:[113705], Breast-ovarian cancer OMIM:[113705], Ovarian cancer OMIM:[113705], Papillary serous carcinoma of the peritoneum OMIM:[113705]
About this Structure
1JNX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1., Williams RS, Green R, Glover JN, Nat Struct Biol. 2001 Oct;8(10):838-42. PMID:11573086
Page seeded by OCA on Sun Mar 30 21:36:21 2008
