5b7b
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Nucleoprotein-nucleozin complex== | |
| - | + | <StructureSection load='5b7b' size='340' side='right' caption='[[5b7b]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5b7b]] is a 6 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4x9a 4x9a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B7B FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NUZ:[4-(2-CHLORO-4-NITROPHENYL)PIPERAZIN-1-YL](5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)METHANONE'>NUZ</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b7b OCA], [http://pdbe.org/5b7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b7b RCSB], [http://www.ebi.ac.uk/pdbsum/5b7b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b7b ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q1K9H2_I33A0 Q1K9H2_I33A0]] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus (By similarity).[SAAS:SAAS002141_004_603280] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Hao, Q]] | [[Category: Hao, Q]] | ||
[[Category: Pang, B]] | [[Category: Pang, B]] | ||
| - | [[Category: Zhang, H | + | [[Category: Zhang, H M]] |
| - | [[Category: Zhang, W | + | [[Category: Zhang, W Z]] |
| + | [[Category: Influenza nucleoprotein]] | ||
| + | [[Category: Nucleozin]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 02:12, 13 July 2016
Crystal structure of Nucleoprotein-nucleozin complex
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