5ee5

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m (Protected "5ee5" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5ee5 is ON HOLD
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==Structure of human ARL1 in complex with the DCB domain of BIG1==
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<StructureSection load='5ee5' size='340' side='right' caption='[[5ee5]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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Authors: Galindo, A., Soler, N., Munro, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ee5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EE5 FirstGlance]. <br>
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Description: Structure of human ARL1 in complex with the DCB domain of BIG1
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dcn|4dcn]], [[1upt|1upt]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ee5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ee5 OCA], [http://pdbe.org/5ee5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ee5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ee5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ee5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/BIG1_HUMAN BIG1_HUMAN]] Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined.<ref>PMID:12571360</ref> <ref>PMID:15644318</ref> <ref>PMID:17227842</ref> <ref>PMID:22084092</ref> <ref>PMID:20360857</ref> [[http://www.uniprot.org/uniprot/ARL1_HUMAN ARL1_HUMAN]] GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.<ref>PMID:9624189</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Galindo, A]]
[[Category: Galindo, A]]
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[[Category: Munro, S]]
[[Category: Soler, N]]
[[Category: Soler, N]]
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[[Category: Munro, S]]
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[[Category: Arf1-gef arl1-effector trans-golgi dcb domain]]
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[[Category: Transcription]]

Revision as of 03:08, 13 July 2016

Structure of human ARL1 in complex with the DCB domain of BIG1

5ee5, resolution 2.28Å

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OCA

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