4ydp

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'''Unreleased structure'''
 
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The entry 4ydp is ON HOLD until Paper Publication
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==Crystal structure of N-terminal PDZ domain of ZASP in complex with myotilin C-terminal peptide.==
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<StructureSection load='4ydp' size='340' side='right' caption='[[4ydp]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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Authors: Grishkovskaya, I., Onipe, A., Kontaxis, G., Djinovic-Carugo, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ydp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YDP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YDP FirstGlance]. <br>
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Description: Crystal structure of N-terminal PDZ domain of ZASP in complex with myotilin C-terminal peptide.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ydp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ydp OCA], [http://pdbe.org/4ydp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ydp RCSB], [http://www.ebi.ac.uk/pdbsum/4ydp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ydp ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/LDB3_HUMAN LDB3_HUMAN]] Defects in LDB3 are the cause of cardiomyopathy dilated type 1C (CMD1C) [MIM:[http://omim.org/entry/601493 601493]]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14662268</ref> <ref>PMID:14660611</ref> Defects in LDB3 are the cause of left ventricular non-compaction type 3 (LVNC3) [MIM:[http://omim.org/entry/601493 601493]]. Left ventricular non-compaction is characterized by numerous prominent trabeculations and deep intertrabecular recesses in hypertrophied and hypokinetic segments of the left ventricle. Defects in LDB3 are the cause of myopathy myofibrillar type 4 (MFM4) [MIM:[http://omim.org/entry/609452 609452]]. A neuromuscular disorder characterized by distal and proximal muscle weakness with signs of cardiomyopathy and neuropathy.
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== Function ==
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[[http://www.uniprot.org/uniprot/LDB3_HUMAN LDB3_HUMAN]] May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.[:]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Djinovic-Carugo, K]]
[[Category: Djinovic-Carugo, K]]
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[[Category: Grishkovskaya, I]]
[[Category: Kontaxis, G]]
[[Category: Kontaxis, G]]
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[[Category: Grishkovskaya, I]]
 
[[Category: Onipe, A]]
[[Category: Onipe, A]]
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[[Category: Myotilin]]
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[[Category: Sarcomere]]
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[[Category: Striated muscle z-disc]]
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[[Category: Structural protein]]
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[[Category: Zasp/ldb3]]

Revision as of 10:12, 13 July 2016

Crystal structure of N-terminal PDZ domain of ZASP in complex with myotilin C-terminal peptide.

4ydp, resolution 1.40Å

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