This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5a4k
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the R139W variant of human NAD(P)H:quinone oxidoreductase== | |
| - | + | <StructureSection load='5a4k' size='340' side='right' caption='[[5a4k]], [[Resolution|resolution]] 2.09Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5a4k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A4K FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | |
| - | [ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(P)H_dehydrogenase_(quinone) NAD(P)H dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.2 1.6.5.2] </span></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4k OCA], [http://pdbe.org/5a4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a4k RCSB], [http://www.ebi.ac.uk/pdbsum/5a4k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4k ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/NQO1_HUMAN NQO1_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Gruber, K]] | [[Category: Gruber, K]] | ||
[[Category: Gudipati, V]] | [[Category: Gudipati, V]] | ||
| - | [[Category: Lienhart, W | + | [[Category: Lienhart, W D]] |
[[Category: Macheroux, P]] | [[Category: Macheroux, P]] | ||
| - | [[Category: Rantase, D | + | [[Category: Rantase, D M]] |
| + | [[Category: Strandback, E]] | ||
| + | [[Category: Uhl, M K]] | ||
| + | [[Category: Zangger, K]] | ||
| + | [[Category: Drug metabolism]] | ||
| + | [[Category: Fad]] | ||
| + | [[Category: Flavoprotein]] | ||
| + | [[Category: Nqo1]] | ||
| + | [[Category: Oxidative stress]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Quinone reductase]] | ||
| + | [[Category: Single amino acid exchange]] | ||
Revision as of 10:16, 13 July 2016
Crystal structure of the R139W variant of human NAD(P)H:quinone oxidoreductase
| |||||||||||
