5bpv
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A== | |
| - | + | <StructureSection load='5bpv' size='340' side='right' caption='[[5bpv]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5bpv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpv OCA], [http://pdbe.org/5bpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpv RCSB], [http://www.ebi.ac.uk/pdbsum/5bpv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpv ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/VP35_EBOZ5 VP35_EBOZ5]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity). |
| - | [[ | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Alcaro, S]] | ||
[[Category: Bianco, G]] | [[Category: Bianco, G]] | ||
| - | [[Category: | + | [[Category: Cannas, V]] |
[[Category: Corona, A]] | [[Category: Corona, A]] | ||
| - | [[Category: | + | [[Category: Daino, G L]] |
| - | + | ||
[[Category: Distinto, S]] | [[Category: Distinto, S]] | ||
| + | [[Category: Esposito, F]] | ||
[[Category: Fadda, V]] | [[Category: Fadda, V]] | ||
| - | [[Category: Taylor, G | + | [[Category: Maccioni, E]] |
| + | [[Category: Taylor, G L]] | ||
| + | [[Category: Tramontano, E]] | ||
| + | [[Category: Zinzula, L]] | ||
| + | [[Category: Interferon inhibitor]] | ||
| + | [[Category: Polymerase cofactor]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 10:17, 13 July 2016
Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A
| |||||||||||
