5bxu

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'''Unreleased structure'''
 
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The entry 5bxu is ON HOLD until Paper Publication
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==Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n4m5==
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<StructureSection load='5bxu' size='340' side='right' caption='[[5bxu]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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Authors: Xu, W., Fischer, G., Hyvonen, M., Itzhaki, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5bxu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BXU FirstGlance]. <br>
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Description: Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n4m5
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4XQ:4,4-PENTANE-1,5-DIYLBIS(1-PROPYL-1H-1,2,3-TRIAZOLE)'>4XQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=GMA:4-AMIDO-4-CARBAMOYL-BUTYRIC+ACID'>GMA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bxu OCA], [http://pdbe.org/5bxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bxu RCSB], [http://www.ebi.ac.uk/pdbsum/5bxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bxu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Fischer, G]]
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[[Category: Hyvonen, M]]
[[Category: Itzhaki, L]]
[[Category: Itzhaki, L]]
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[[Category: Hyvonen, M]]
 
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[[Category: Fischer, G]]
 
[[Category: Xu, W]]
[[Category: Xu, W]]
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[[Category: Ankyrin-repeat domain]]
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[[Category: Protein-protein interaction]]
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[[Category: Stapled peptide]]
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[[Category: Tankyrase]]
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[[Category: Transferase]]

Revision as of 10:18, 13 July 2016

Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n4m5

5bxu, resolution 1.35Å

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