5c4m

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m (Protected "5c4m" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5c4m is ON HOLD
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==RhoA GDP with novel switch II conformation==
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<StructureSection load='5c4m' size='340' side='right' caption='[[5c4m]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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Authors: Pellegrini, E., Bowler, M.W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5c4m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C4M FirstGlance]. <br>
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Description: RhoA GDP with novel switch II conformation
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c4m OCA], [http://pdbe.org/5c4m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c4m RCSB], [http://www.ebi.ac.uk/pdbsum/5c4m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c4m ProSAT]</span></td></tr>
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[[Category: Bowler, M.W]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bowler, M W]]
[[Category: Pellegrini, E]]
[[Category: Pellegrini, E]]
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[[Category: Rhoa small g protein off-state gdp bound]]
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[[Category: Signaling protein]]

Revision as of 10:19, 13 July 2016

RhoA GDP with novel switch II conformation

5c4m, resolution 1.30Å

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