5h9p
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Human Galectin-3 CRD in Complex with TD139== | |
| - | + | <StructureSection load='5h9p' size='340' side='right' caption='[[5h9p]], [[Resolution|resolution]] 2.04Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5h9p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H9P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TD2:3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>TD2</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xbn|4xbn]], [[5h9q|5h9q]], [[5h9r|5h9r]], [[5h9s|5h9s]]</td></tr> |
| - | [[Category: Hsieh, T | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9p OCA], [http://pdbe.org/5h9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h9p RCSB], [http://www.ebi.ac.uk/pdbsum/5h9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9p ProSAT]</span></td></tr> |
| - | [[Category: Lin, H | + | </table> |
| - | [[Category: Lin, | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hsieh, T J]] | ||
| + | [[Category: Lin, C H]] | ||
| + | [[Category: Lin, H Y]] | ||
| + | [[Category: Galectin]] | ||
| + | [[Category: Pi-arginine interaction]] | ||
| + | [[Category: Sugar binding protein]] | ||
Revision as of 10:23, 13 July 2016
Crystal Structure of Human Galectin-3 CRD in Complex with TD139
| |||||||||||
