5jh7
From Proteopedia
(Difference between revisions)
m (Protected "5jh7" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Tubulin-Eribulin complex== | |
| - | + | <StructureSection load='5jh7' size='340' side='right' caption='[[5jh7]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5jh7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JH7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=03S:METHANESULFONIC+ACID'>03S</scene>, <scene name='pdbligand=6K9:(1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-AMINO-2-HYDROXYPROPYL]-21-METHOXY-14-METHYL-8,15-DIMETHYLIDENE-2,19,30,34,37,39,40,41-OCTAOXANONACYCLO[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]HENTETRACONTAN-24-ONE+(NON-PREFERRED+NAME)'>6K9</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jh7 OCA], [http://pdbe.org/5jh7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jh7 RCSB], [http://www.ebi.ac.uk/pdbsum/5jh7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jh7 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Akhmanova, A]] | ||
| + | [[Category: Bargsten, K]] | ||
[[Category: Cox, D]] | [[Category: Cox, D]] | ||
| + | [[Category: Custar, D W]] | ||
| + | [[Category: Doodhi, H]] | ||
[[Category: Grigoriev, I]] | [[Category: Grigoriev, I]] | ||
| - | [[Category: | + | [[Category: Hilbert, M]] |
| - | [[Category: | + | [[Category: Horwitz, S Band]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
[[Category: Hua, S]] | [[Category: Hua, S]] | ||
| - | [[Category: | + | [[Category: Jiang, K]] |
| - | [[Category: | + | [[Category: Kapitein, L C]] |
| - | [[Category: Katrukha, E | + | [[Category: Katrukha, E A]] |
| + | [[Category: Prota, A E]] | ||
[[Category: Rodriguez-Garcia, R]] | [[Category: Rodriguez-Garcia, R]] | ||
| - | [[Category: | + | [[Category: Steinmetz, M O]] |
| - | [[Category: | + | [[Category: Xiao, H]] |
| + | [[Category: Yang, C P.H]] | ||
| + | [[Category: Cell cycle]] | ||
| + | [[Category: Cytoskeleton]] | ||
| + | [[Category: Microtubule]] | ||
| + | [[Category: Tubulin fold]] | ||
Revision as of 10:26, 13 July 2016
Tubulin-Eribulin complex
| |||||||||||
Categories: Bos taurus | Akhmanova, A | Bargsten, K | Cox, D | Custar, D W | Doodhi, H | Grigoriev, I | Hilbert, M | Horwitz, S Band | Hua, S | Jiang, K | Kapitein, L C | Katrukha, E A | Prota, A E | Rodriguez-Garcia, R | Steinmetz, M O | Xiao, H | Yang, C P.H | Cell cycle | Cytoskeleton | Microtubule | Tubulin fold
