5fg0

From Proteopedia

(Difference between revisions)

Revision as of 17:59, 13 July 2016

Structure of the conserved yeast listerin (Ltn1) N-terminal domain, MONOCLINIC FORM

Structural highlights

5fg0 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	5fg1
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LTN1_YEAST] E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123). Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product (PubMed:20835226, PubMed:23825054, PubMed:24261871). May indirectly play a role in chromatin function and transcription (PubMed:17283062).^[1] ^[2] ^[3] ^[4] ^[5]

References

↑ Braun MA, Costa PJ, Crisucci EM, Arndt KM. Identification of Rkr1, a nuclear RING domain protein with functional connections to chromatin modification in Saccharomyces cerevisiae. Mol Cell Biol. 2007 Apr;27(8):2800-11. Epub 2007 Feb 5. PMID:17283062 doi:http://dx.doi.org/10.1128/MCB.01947-06
↑ Bengtson MH, Joazeiro CA. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature. 2010 Sep 23;467(7314):470-3. doi: 10.1038/nature09371. Epub 2010 Sep 12. PMID:20835226 doi:http://dx.doi.org/10.1038/nature09371
↑ Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell. 2012 Nov 21;151(5):1042-54. doi: 10.1016/j.cell.2012.10.044. PMID:23178123 doi:http://dx.doi.org/10.1016/j.cell.2012.10.044
↑ Letzring DP, Wolf AS, Brule CE, Grayhack EJ. Translation of CGA codon repeats in yeast involves quality control components and ribosomal protein L1. RNA. 2013 Sep;19(9):1208-17. doi: 10.1261/rna.039446.113. Epub 2013 Jul 3. PMID:23825054 doi:http://dx.doi.org/10.1261/rna.039446.113
↑ Matsuda R, Ikeuchi K, Nomura S, Inada T. Protein quality control systems associated with no-go and nonstop mRNA surveillance in yeast. Genes Cells. 2014 Jan;19(1):1-12. doi: 10.1111/gtc.12106. Epub 2013 Nov 21. PMID:24261871 doi:http://dx.doi.org/10.1111/gtc.12106

1 Structural highlights
2 Function
3 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5fg0"

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5fg0 is ON HOLD  until Paper Publication
+==Structure of the conserved yeast listerin (Ltn1) N-terminal domain, MONOCLINIC FORM==
+<StructureSection load='5fg0' size='340' side='right' caption='[[5fg0]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fg0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FG0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FG0 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fg1|5fg1]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fg0 OCA], [http://pdbe.org/5fg0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fg0 RCSB], [http://www.ebi.ac.uk/pdbsum/5fg0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fg0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/LTN1_YEAST LTN1_YEAST]] E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123). Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product (PubMed:20835226, PubMed:23825054, PubMed:24261871). May indirectly play a role in chromatin function and transcription (PubMed:17283062).<ref>PMID:17283062</ref> <ref>PMID:20835226</ref> <ref>PMID:23178123</ref> <ref>PMID:23825054</ref> <ref>PMID:24261871</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Doamekpor, S K]]
+[[Category: Lima, C D]]
+[[Category: Ligase]]
+[[Category: Protein quality control]]
+[[Category: Ribosome]]
+[[Category: Ubiquitin ligase]]

5fg0

From Proteopedia

Revision as of 17:59, 13 July 2016

Structure of the conserved yeast listerin (Ltn1) N-terminal domain, MONOCLINIC FORM

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox