5itx

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m (Protected "5itx" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5itx is ON HOLD until Paper Publication
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==Crystal Structure of Human NEIL1(P2G R242K) bound to duplex DNA containing Thymine Glycol==
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<StructureSection load='5itx' size='340' side='right' caption='[[5itx]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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Authors: Zhu, C., Lu, L., Zhang, J., Yue, Z., Song, J., Zong, S., Liu, M., Stovicek, O., Gao, Y., Yi, C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5itx]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ITX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ITX FirstGlance]. <br>
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Description: Crystal Structure of Human NEIL1(P2G R242K) bound to duplex DNA containing Thymine Glycol
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CTG:(5R,6S)-5,6-DIHYDRO-5,6-DIHYDROXYTHYMIDINE-5-MONOPHOSPHATE'>CTG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ity|5ity]], [[5itq|5itq]], [[5itt|5itt]], [[5itr|5itr]], [[5itu|5itu]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5itx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5itx OCA], [http://pdbe.org/5itx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5itx RCSB], [http://www.ebi.ac.uk/pdbsum/5itx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5itx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/NEIL1_HUMAN NEIL1_HUMAN]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.<ref>PMID:12200441</ref> <ref>PMID:12509226</ref> <ref>PMID:11904416</ref> <ref>PMID:14522990</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gao, Y]]
[[Category: Liu, M]]
[[Category: Liu, M]]
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[[Category: Zhu, C]]
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[[Category: Lu, L]]
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[[Category: Zhang, J]]
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[[Category: Song, J]]
[[Category: Stovicek, O]]
[[Category: Stovicek, O]]
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[[Category: Gao, Y]]
 
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[[Category: Lu, L]]
 
[[Category: Yi, C]]
[[Category: Yi, C]]
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[[Category: Song, J]]
 
[[Category: Yue, Z]]
[[Category: Yue, Z]]
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[[Category: Zhang, J]]
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[[Category: Zhu, C]]
[[Category: Zong, S]]
[[Category: Zong, S]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Dna glycosylase neil1 fpg nei base excision repair]]

Revision as of 18:02, 13 July 2016

Crystal Structure of Human NEIL1(P2G R242K) bound to duplex DNA containing Thymine Glycol

5itx, resolution 2.65Å

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OCA

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