5l5g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Plexin A2 full extracellular region, domains 1 to 8 modeled, data to 10 angstrom== | |
| - | + | <StructureSection load='5l5g' size='340' side='right' caption='[[5l5g]], [[Resolution|resolution]] 10.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5l5g]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L5G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l5g OCA], [http://pdbe.org/5l5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l5g RCSB], [http://www.ebi.ac.uk/pdbsum/5l5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l5g ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PLXA2_MOUSE PLXA2_MOUSE]] Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref> <ref>PMID:20877282</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Coles, C H]] | ||
| + | [[Category: Gilbert, R J.C]] | ||
| + | [[Category: Janssen, B J.C]] | ||
| + | [[Category: Jones, E Y]] | ||
| + | [[Category: Kaufmann, R]] | ||
| + | [[Category: Kong, Y]] | ||
| + | [[Category: Malinauskas, T]] | ||
| + | [[Category: Ni, T]] | ||
| + | [[Category: Padilla-Parra, S]] | ||
| + | [[Category: Pasterkamp, R J]] | ||
| + | [[Category: Vangoor, V R]] | ||
| + | [[Category: Axon guidance]] | ||
| + | [[Category: Receptor]] | ||
| + | [[Category: Signaling]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 18:05, 13 July 2016
Plexin A2 full extracellular region, domains 1 to 8 modeled, data to 10 angstrom
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