1jya
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1jya |SIZE=350|CAPTION= <scene name='initialview01'>1jya</scene>, resolution 1.74Å | |PDB= 1jya |SIZE=350|CAPTION= <scene name='initialview01'>1jya</scene>, resolution 1.74Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= syce ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=633 Yersinia pseudotuberculosis]) | |GENE= syce ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=633 Yersinia pseudotuberculosis]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jya OCA], [http://www.ebi.ac.uk/pdbsum/1jya PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jya RCSB]</span> | ||
}} | }} | ||
| Line 27: | Line 30: | ||
[[Category: type iii secretion]] | [[Category: type iii secretion]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:40:45 2008'' |
Revision as of 18:40, 30 March 2008
| |||||||
| , resolution 1.74Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | syce (Yersinia pseudotuberculosis) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of SycE
Overview
In the type III secretory system of bacterial pathogens, a large number of sequence-divergent but characteristically small (approximately 14-19 kDa), acidic (pI approximately 4-5) chaperone proteins have been identified. We present the 1.74 A resolution crystal structure of the Yersinia pseudotuberculosis chaperone SycE, whose action in promoting translocation of YopE into host macrophages is essential to Yersinia pathogenesis. SycE, a compact, globular dimer with a novel fold, has two large hydrophobic surface patches that may form binding sites for YopE or other type III components. These patches are formed by structurally key residues that are conserved among many chaperones, suggesting shared structural and functional relationships. A negative electrostatic potential covers almost the entire surface of SycE and is likely conserved in character, but not in detail, among chaperones. The structure provides the first structural insights into possible modes of action of SycE and type III chaperones in general.
About this Structure
1JYA is a Single protein structure of sequence from Yersinia pseudotuberculosis. Full crystallographic information is available from OCA.
Reference
Structure of the Yersinia type III secretory system chaperone SycE., Birtalan S, Ghosh P, Nat Struct Biol. 2001 Nov;8(11):974-8. PMID:11685245
Page seeded by OCA on Sun Mar 30 21:40:45 2008
