5e8j
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with RAM== | |
| - | + | <StructureSection load='5e8j' size='340' side='right' caption='[[5e8j]], [[Resolution|resolution]] 2.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5e8j]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E8J FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bgv|3bgv]], [[3epp|3epp]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/mRNA_(guanine-N(7)-)-methyltransferase mRNA (guanine-N(7)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.56 2.1.1.56] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8j OCA], [http://pdbe.org/5e8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e8j RCSB], [http://www.ebi.ac.uk/pdbsum/5e8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e8j ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MCES_HUMAN MCES_HUMAN]] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:9790902</ref> <ref>PMID:9705270</ref> <ref>PMID:10347220</ref> <ref>PMID:22099306</ref> [[http://www.uniprot.org/uniprot/RAM_HUMAN RAM_HUMAN]] Required for efficient mRNA cap methylation. Regulates RNMT expression by a post-transcriptional stabilizing mechanism.<ref>PMID:22099306</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cowling, V]] | ||
[[Category: Petit, P]] | [[Category: Petit, P]] | ||
| - | [[Category: | + | [[Category: Mrna capping]] |
| + | [[Category: Mrna processing]] | ||
| + | [[Category: Translation]] | ||
Revision as of 11:43, 14 July 2016
Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with RAM
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