5f28
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of FAT domain of Focal Adhesion Kinase (FAK) bound to the transcription factor MEF2C== | |
| - | + | <StructureSection load='5f28' size='340' side='right' caption='[[5f28]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5f28]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F28 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f28 OCA], [http://pdbe.org/5f28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f28 RCSB], [http://www.ebi.ac.uk/pdbsum/5f28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f28 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MEF2C_MOUSE MEF2C_MOUSE]] Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1, isoform 2 and isoform 5 (By similarity). Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells.[UniProtKB:Q06413]<ref>PMID:18086704</ref> <ref>PMID:18438409</ref> <ref>PMID:18599437</ref> <ref>PMID:18599438</ref> <ref>PMID:19211936</ref> <ref>PMID:9162005</ref> <ref>PMID:9778514</ref> [[http://www.uniprot.org/uniprot/FAK1_MOUSE FAK1_MOUSE]] Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 9 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription (By similarity).<ref>PMID:7997267</ref> <ref>PMID:7478517</ref> <ref>PMID:9148935</ref> <ref>PMID:10373530</ref> <ref>PMID:10806474</ref> <ref>PMID:11278462</ref> <ref>PMID:11369769</ref> <ref>PMID:12941275</ref> <ref>PMID:12702722</ref> <ref>PMID:15967814</ref> <ref>PMID:16000375</ref> <ref>PMID:16391003</ref> <ref>PMID:17093062</ref> <ref>PMID:18206965</ref> <ref>PMID:19473962</ref> <ref>PMID:19147981</ref> <ref>PMID:22056317</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ambrosio, A L.B]] | ||
| + | [[Category: Cardoso, A C]] | ||
[[Category: Dessen, A]] | [[Category: Dessen, A]] | ||
| - | [[Category: Franchini, K | + | [[Category: Franchini, K G]] |
| - | [[Category: | + | [[Category: Cardiovascular disease]] |
| - | [[Category: | + | [[Category: Kinase]] |
| + | [[Category: Protein binding]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription factor]] | ||
Revision as of 11:44, 14 July 2016
Crystal structure of FAT domain of Focal Adhesion Kinase (FAK) bound to the transcription factor MEF2C
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