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5hv9
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human LTC4S mutant-S36E== | |
| - | + | <StructureSection load='5hv9' size='340' side='right' caption='[[5hv9]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hv9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HV9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-C(4)_synthase Leukotriene-C(4) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.20 4.4.1.20] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hv9 OCA], [http://pdbe.org/5hv9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hv9 RCSB], [http://www.ebi.ac.uk/pdbsum/5hv9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hv9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ahmad, H R.S]] | ||
| + | [[Category: Haeggstrom, J Z]] | ||
| + | [[Category: Rinaldo-Matthis, A]] | ||
[[Category: Thulasingam, M]] | [[Category: Thulasingam, M]] | ||
| - | [[Category: | + | [[Category: Ltc4]] |
| - | [[Category: | + | [[Category: Lyase]] |
| - | [[Category: | + | [[Category: Mutant]] |
Revision as of 11:45, 14 July 2016
Human LTC4S mutant-S36E
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