1k0s
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= CheW ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima]) | |GENE= CheW ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0s OCA], [http://www.ebi.ac.uk/pdbsum/1k0s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k0s RCSB]</span> | ||
}} | }} | ||
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[[Category: chew]] | [[Category: chew]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:41:44 2008'' |
Revision as of 18:41, 30 March 2008
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| Gene: | CheW (Thermotoga maritima) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of the chemotaxis protein CheW from the thermophilic organism Thermotoga maritima
Overview
Using protein from the hyperthermophile Thermotoga maritima, we have determined the solution structure of CheW, an essential component in the formation of the bacterial chemotaxis signaling complex. The overall fold is similar to the regulatory domain of the chemotaxis kinase CheA. In addition, interactions of CheW with CheA were monitored by nuclear magnetic resonance (NMR) techniques. The chemical shift perturbation data show the probable contacts that CheW makes with CheA. In combination with previous genetic data, the structure also suggests a possible binding site for the chemotaxis receptor. These results provide a structural basis for a model in which CheW acts as a molecular bridge between CheA and the cytoplasmic tails of the receptor.
About this Structure
1K0S is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
Reference
The solution structure and interactions of CheW from Thermotoga maritima., Griswold IJ, Zhou H, Matison M, Swanson RV, McIntosh LP, Simon MI, Dahlquist FW, Nat Struct Biol. 2002 Feb;9(2):121-5. PMID:11799399
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