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5lc0
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lc0 OCA], [http://pdbe.org/5lc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lc0 RCSB], [http://www.ebi.ac.uk/pdbsum/5lc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lc0 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lc0 OCA], [http://pdbe.org/5lc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lc0 RCSB], [http://www.ebi.ac.uk/pdbsum/5lc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lc0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The ongoing Zika virus (ZIKV) outbreak is linked to severe neurological disorders. ZIKV relies on its NS2B/NS3 protease for polyprotein processing; hence, this enzyme is an attractive drug target. The 2.7 A crystal structure of ZIKV protease in complex with a peptidomimetic boronic-acid inhibitor reveals a cyclic diester between the boronic acid and glycerol. The P2 4-aminomethylphenylalanine moiety of the inhibitor forms a salt-bridge with the non-conserved Asp83 of NS2B, Ion-pairing between Asp83 and the P2 residue of the substrate likely accounts for the enzyme's high catalytic efficiency. The unusual dimer of the ZIKV protease:inhibitor complex seen in the crystal may provide a model for assemblies formed at high local concentrations of protease at the endoplasmatic reticulum membrane, the site of polyprotein processing. | ||
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| + | Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.,Lei J, Hansen G, Nitsche C, Klein CD, Zhang L, Hilgenfeld R Science. 2016 Jul 7. pii: aag2419. PMID:27386922<ref>PMID:27386922</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5lc0" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:46, 26 July 2016
Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor
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