1k4r
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1svb|1svb]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k4r OCA], [http://www.ebi.ac.uk/pdbsum/1k4r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k4r RCSB]</span> | ||
}} | }} | ||
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[[Category: icosahedral virus]] | [[Category: icosahedral virus]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:43:27 2008'' |
Revision as of 18:43, 30 March 2008
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| , resolution 24.Å | |||||||
|---|---|---|---|---|---|---|---|
| Related: | 1svb
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of Dengue Virus
Overview
The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane.
About this Structure
1K4R is a Single protein structure of sequence from Tick-borne encephalitis virus. Full crystallographic information is available from OCA.
Reference
Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:11893341
Page seeded by OCA on Sun Mar 30 21:43:27 2008
Categories: Single protein | Tick-borne encephalitis virus | Baker, T S. | Chipman, P R. | Corver, J. | Jones, C T. | Kuhn, R J. | Lenches, E. | Mukhopadhyay, S. | Pletnev, S V. | Rossmann, M G. | Strauss, E G. | Strauss, J H. | Zhang, W. | Dengue virus | Flaviviridae | Flavivirus | Glycoprotein e from tick-borne encephalitis virus | Icosahedral virus
